Detalhe da pesquisa
1.
Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M ß-Lactamases: Biochemical and Structural Analyses.
Antimicrob Agents Chemother
; 67(1): e0093022, 2023 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36602311
2.
Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas-derived cephalosporinase.
Antimicrob Agents Chemother
; 67(11): e0079123, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37850746
3.
Different Conformations Revealed by NMR Underlie Resistance to Ceftazidime/Avibactam and Susceptibility to Meropenem and Imipenem among D179Y Variants of KPC ß-Lactamase.
Antimicrob Agents Chemother
; 66(4): e0212421, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35311523
4.
Imipenem/Relebactam Resistance in Clinical Isolates of Extensively Drug Resistant Pseudomonas aeruginosa: Inhibitor-Resistant ß-Lactamases and Their Increasing Importance.
Antimicrob Agents Chemother
; 66(5): e0179021, 2022 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35435707
5.
Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog.
Antimicrob Agents Chemother
; 64(12)2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32988830
6.
Insights into the l,d-Transpeptidases and d,d-Carboxypeptidase of Mycobacterium abscessus: Ceftaroline, Imipenem, and Novel Diazabicyclooctane Inhibitors.
Antimicrob Agents Chemother
; 64(8)2020 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32393499
7.
A Standard Numbering Scheme for Class C ß-Lactamases.
Antimicrob Agents Chemother
; 64(3)2020 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31712217
8.
Resurrecting Old ß-Lactams: Potent Inhibitory Activity of Temocillin against Multidrug-Resistant Burkholderia Species Isolates from the United States.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30718248
9.
The Reaction Mechanism of Metallo-ß-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.
Antimicrob Agents Chemother
; 63(1)2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30348667
10.
Beyond Piperacillin-Tazobactam: Cefepime and AAI101 as a Potent ß-Lactam-ß-Lactamase Inhibitor Combination.
Antimicrob Agents Chemother
; 63(5)2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858223
11.
Nacubactam Enhances Meropenem Activity against Carbapenem-Resistant Klebsiella pneumoniae Producing KPC.
Antimicrob Agents Chemother
; 63(8)2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31182530
12.
Multiple substitutions lead to increased loop flexibility and expanded specificity in Acinetobacter baumannii carbapenemase OXA-239.
Biochem J
; 475(1): 273-288, 2018 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29229762
13.
Characterization of the AmpC ß-Lactamase from Burkholderia multivorans.
Antimicrob Agents Chemother
; 62(10)2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012762
14.
Relebactam Is a Potent Inhibitor of the KPC-2 ß-Lactamase and Restores Imipenem Susceptibility in KPC-Producing Enterobacteriaceae.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29610205
15.
Exploring the Role of the Ω-Loop in the Evolution of Ceftazidime Resistance in the PenA ß-Lactamase from Burkholderia multivorans, an Important Cystic Fibrosis Pathogen.
Antimicrob Agents Chemother
; 61(2)2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27872073
16.
Exploring the Landscape of Diazabicyclooctane (DBO) Inhibition: Avibactam Inactivation of PER-2 ß-Lactamase.
Antimicrob Agents Chemother
; 61(6)2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28348157
17.
Avibactam Restores the Susceptibility of Clinical Isolates of Stenotrophomonas maltophilia to Aztreonam.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28784669
18.
Boronic Acid Transition State Inhibitors Active against KPC and Other Class A ß-Lactamases: Structure-Activity Relationships as a Guide to Inhibitor Design.
Antimicrob Agents Chemother
; 60(3): 1751-9, 2016 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26729496
19.
Exposing a ß-Lactamase "Twist": the Mechanistic Basis for the High Level of Ceftazidime Resistance in the C69F Variant of the Burkholderia pseudomallei PenI ß-Lactamase.
Antimicrob Agents Chemother
; 60(2): 777-88, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26596949
20.
Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D ß-lactamases from Acinetobacter baumannii.
Biochemistry
; 54(10): 1976-87, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25710192